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Regulation of gene expression by protein methylation

The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Asso...

专利类别:   发明专利
发明设计人:   
院系部门:   
申请日期:   2011-01-01
申请号/专利号:   8148124
专利简介: The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.
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